Hematopoietic stimulants help your bone marrow make new white blood cells. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. More than 7100 monographs are provided for prescription and overthecounter drugs, as well as for corresponding brandname drugs, herbals, and supplements. In animals, reduced circulating red blood cells and leukocyte populations correlated with microscopic findings in the bone marrow, thymus, spleen and liver.
Once a hematopoietic stem cell is committed to enter a programmed series of cell division, the defect in chromosomal replication results in inability of maturing cells to complete nuclear division while cytoplasmic maturation continues at. Chapter 17 hematopoietic drugs classification of hematopoietic drugs minerals ferrous sulfatea iron dextranb vitamins folic acid cyanocobalamin vitamin b12, calomist, nascobal hydroxocobalamin vitamin b12, cyanokit hematopoietic growth factors epoetin alfa epogen, procrit epoetin beta mircera darbepoetin alfa aranesp. Adams, veterinary pharmacology and therapeutics 7th ed. Start studying drugs affecting the hematopoietic system. Network pharmacologybased investigation of the systemlevel. Sep 27, 2011 cancer drug discovery programs involving cancer stem cells as a platform offer a discovery process with a high degree of therapeutic efficiency. Drugs affecting the hematopoietic system multiple choice 1.
Drugs acting on blood andor blood forming organs sciencedirect. Clinical trials are testing hematopoietic stimulants to see if they help people with some types of cancer. Blood cells originate from a small pool of hematopoietic stem cells hscs through a complex process of differentiation steps that are tightly regulated at. Hematopoietic pharmacology students will be able to. Drugs acting on the blood and blood forming authorstream. Md0806 51 lesson assignment subcourse 806 therapeutics iii. Jul 23, 2016 chapter 17 hematopoietic drugs classification of hematopoietic drugs minerals ferrous sulfatea iron dextranb vitamins folic acid cyanocobalamin vitamin b12, calomist, nascobal hydroxocobalamin vitamin b12, cyanokit hematopoietic growth factors epoetin alfa epogen, procrit epoetin beta mircera darbepoetin alfa aranesp filgrastim neupogen. Hematopoietic drugshematopoietic drugs introduction hematopoiesis formation of blood is a complex process of proliferation, differentiation, and maturation of cellular components of blood erythrocytes, leucocytes and platelets from the bone marrow stem cells. Positive and negative signals are crucial in the regulation of the hematopoietic system. Drugs acting on haematopoietic system of animals folic acid. During embryonic development, this function is performed mainly in the spleen, liver and bone marrow, and after the birth the production of these elements is performed mainly by the bone marrow and the lymph. Hematopoietic system definition is an organic system of the body consisting of the blood and the structures that function in its production. All blood cells start off as hematopoietic stem cells, and then. The mature blood cells differ in structure and function, but all develop from a common progenitor cell, or stem cell, from within the bone marrow.
This is a tutoriallecture on the drugs affecting haematopoiesis. Ch18 chapter 18 drugs affecting the hematopoietic system. Haemopoietic growth factors are involved in the production of the various blood cells from progenitors in the bone marrow, making them useful in a range of clinical situations. Drugs acting on haematopoietic system of animals view presentation slides online. Hematopoietic growth factors, proteins that regulate the proliferation and differentiation of hematopoietic cells, are also required. For convenience it is often divided into discrete systems even though there are extensive interactions. Drugs affecting hematopoiesis johns hopkins university. Sellon and others published disorders of the hematopoietic system find, read and cite all the research you need on researchgate. Anticoagulant, thrombolytic, and antiplatelet drugs katzung 9th ed. Given a group of statements, select the statement which best describes hematopoietic drugs. Abridged standard formulary the following is a list of the most commonly prescribed brand medications. Lesson objectives after completing this lesson you will be able to. More specifically, the production of hematopoietic stem cell selfrenewal.
Dec 14, 2012 haemopoietic system metabolic defects g6pd deficiency pk deficiency hb defects quantitaive defects thalassaemias qualitative defects sickle cell anaemia hbc, d, e unstable hb 14. We cover some topics important for classes such as biochemistry and pharmacology. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may. Haemopoietic system metabolic defects g6pd deficiency pk deficiency hb defects quantitaive defects thalassaemias qualitative defects sickle cell anaemia hbc, d, e unstable hb 14. Monocytemacrophage system thymus accessory lymphoid tissues malt, tonsils some portions of the hematopoietic system are easily accessible to clinicians and provide valuable information about the health status of the patient eg blood smears and.
Hematopoietic effects are most common with some of the older, long acting sulfonamides and include acute hemolytic anemia, agranulocytosis, and aplastic anemia. Drugs used to stimulate bone marrow activity will be the focus of this article. May 07, 2014 hematopoiesis is the process of creating new blood cells in the body. Monocytemacrophage system thymus accessory lymphoid tissues malt, tonsils some portions of the hematopoietic system are easily accessible to clinicians and provide valuable information about the health status of the patient eg blood smears and peripheral lymph node aspirates. Kenneth is taking warfarin and is asking about what he can take for minor aches and pains. Hematopoietic drugshematopoietic drugs introduction. Classify or list drugs which affect the hematopoietic system identify their pharmacological effects interprete mechanisms of actions, kinetics and toxicity correlate these knowledge to form the basis for their rational use in a given clinical situation. Topic wise pharmacology questions and answers pdf 2020. Drugs acting on the immune system the immune system discriminates self from nonself allowing it to destroy infectious invaders or tumors while leaving normal cells intact. The list is not allinclusive and does not guarantee coverage. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Drugs affecting the hematopoietic system multiple choice identify the choice that best completes the statement or answers the question. Vit b 12 deficiency is recognized clinically by its impact on the hematopoietic and nervous system.
Dna synthesis, acting on cells in the s phase of the cell. The respiratory system and respiratory system drugs. Two components, innate and adaptive provide an early active response and an antigenspecific response, respectively. Chapter pages 1 general principles of pharmacology 5 agents. The genes for several of them have been cloned and their production engineered by recombinant technology, making them widely available. Hematopoiesis is the process of creating new blood cells in the body. Hematopoietic system definition of hematopoietic system by. Cardiotonic drugs vasodilators antihypercholesterolemic drugs acting on the hematopoietic system anticoagulant and coagulant drugs 2. The angiotensin peptides may act as locally active growth factors or inhibitors and are. During embryonic development, this function is performed mainly in the spleen, liver and bone marrow, and after the birth the production of these elements is performed mainly by. This leads to mobilization of hematopoietic stem cells to the peripheral blood. Hematopoietic stem cell transplantation hsct is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.
Cancer drug discovery programs involving cancer stem cells as a platform offer a discovery process with a high degree of therapeutic efficiency. Dosing, uses, side effects, interactions, patient handouts, pricing and more from medscape reference. One population of adult stem cells, called hematopoietic stem and progenitor cells hspcs, 4 has the ability to repopulate the hematopoietic system by proliferating and differentiating into all of the necessary lymphoid, myeloid, and erythroid lineages 1, 2. Hematopoietic stem cell mobilizer binds to the cxcr4 chemokine receptor and inhibits the binding of its ligand, stromal cellderived factor1alpha sdf1alpha. Once a hematopoietic stem cell is committed to enter a programmed series of cell division, the defect in chromosomal replication results in inability of maturing cells. However, it remains unknown whether vegf can inhibit the apop totic cell death that is induced by other agents, such as chemothera peutic drugs, and the molecular mechanisms underlying this inhibitory effect of vegf remain to be elucidated. Drugs affecting the hematopoietic system drugs affecting. Chapter 17 hematopoietic drugs classification of hematopoietic drugs minerals ferrous sulfatea iron dextranb vitamins folic acid cyanocobalamin vitamin b12, calomist, nascobal hydroxocobalamin vitamin b12, cyanokit hematopoietic growth factors epoetin alfa epogen, procrit epoetin beta mircera darbepoetin alfa aranesp filgrastim neupogen.
The hematopoietic machinery resides primarily in the bone marrow in adults and requires a constant supply of essential nutrients such as iron, vitamin b 12, and folic acid. Hematopoiesis hematologic system diseases nclexrn khan. All blood cells start off as hematopoietic stem cells, and then specialize differentiate into myeloid cells erythrocytes, megakaryocytes, monocytes, neutrophils, basophils, or eosinophils or lymphoid cells tlymphocytes and blymphocytes. The hematopoietic system is formed by bodies responsible for haematopoiesis, or the production of the cellular elements of blood. Disruption of the hematopoietic system is known to cause various. Drugs acting on the immune system pharmacology education.
You need white blood cells to prevent or fight infection while you are being treated with chemotherapy. Hematopoietic system definition of hematopoietic system. The finite life span of most mature blood cells requires their continuous replacement, a process termed hematopoiesis. Learn vocabulary, terms, and more with flashcards, games, and other study tools. It represents an abbreviated version of the drug list formulary that is at the core of your prescription drug benefit plan. The bodily system of organs and tissues, primarily the bone marrow, spleen. We, the center for biologics evaluation and research cber, fda, are providing advice to you, potential sponsors e. During mammalian embryogenesis, the hematopoietic system is formed from mesodermally. Drugs affecting the hematopoietic system flashcards quizlet. Request pdf hematopoietic agents hematopoesis is a lifelong process that. Vascular endothelial growth factor inhibits apoptotic death. Leukopenia hematopoietic system is composed of a wide range of lymphoid tissues and all the fixed and circulating blood cells originating from pluripotent precursors cells in the bone marrow.
The hematopoietic system consists of a complex network of. Crystalluria can occur, especially with the older, less soluble agents, but it is unlikely to with the newer, more soluble agents, such as sulfisoxazole. Drugs acting on the blood and blood forming authorstream presentation. All blood cells start off as hematopoietic stem cells, and then specialize differentiate into myeloid cells erythrocytes. Therefore, drugs acting on the hematopoietic system would pertain to drugs that act on the blood producing system. Nov 30, 2012 this is a tutoriallecture on the drugs affecting haematopoiesis. Hematopoietic effects are most common with some of the older, longacting sulfonamides and include acute hemolytic anemia, agranulocytosis, and aplastic anemia.
Hematopoietic stem cell transplantation hsct overview. We cover some topics important for classes such as biochemistry and. A new earlyacting hematopoietic growth factor, steel factor slf, has. Chapter 34 this version has been changed compared to the one made available on wednesday april 26 sorry. Given a group of statements, select the statement which best describes hematopoietic. Study organotropic agents drugs acting on hematopoietic system flashcards from tiago rodriguess class online, or in brainscapes iphone or android app. Organotropic agents drugs acting on hematopoietic system.