Such lesions are benign, locally aggressive, nonodontogenic. Fibrous hyperplastic connective tissue lesions are common in the oral cavity and may be similar both clinically and histologically. Fibroadenoma means a tumor composed of glandular related to gland and fibrous containing fibers tissues. It is a localized reactive proliferation of fibrous connective tissue. Cases such as this are rare and we believe that our research adds to the literature concerning this area of study.
Fibroadenoma definition fibroadenomas are benign breast tumors commonly found in young women. Dentists should be aware of the existence of giant cell fibroma in children, which must be included in the differential diagnosis of nodular lesions of the gingiva and adequately diagnosed and treated by removal and histopathological examination. Different forms of fibrous hyperplasia share a similar clinical features, age. Here we are presenting a case where a sevenyearold male patient reported with a painless. The origin of the giant cell is still controversial. Case report giant cell tumor of the maxilla in an 8 year.
It is often mistaken with fibroma and papilloma due to its clinical resemblance. Ameloblastic fibroma cementifying and ossifying fibromas osteolytic stage giant cell and nonodontogenic tumors. Giant cell fibroma is a form of fibrous tumour affecting the oral mucosa. Back of thigh, inguinal region and chest wall are the most common sites of involvement. It presents as a sessile or pedunculated nodule, usually less than 1 cm in diameter with a flat or papillary surface. It is a localized reactive proliferation of fibrous connective tissue giantcell fibroma gcf is a benign nonneoplastic lesion first described by weathers. It makes up less than 5% of odontogenic tumors and is more commonly seen in females. It may be on a small stalk pedunculated or domeshaped like a limpet. Clinically it is presented as a painless, sessile, or pedunculated growth which is usually confused with other fibrous lesions like irritation fibromas.
Giant cell fibroma gcf is an extremely rare histopathological entity characterized by uninucleated or multinucleated giant fibroblasts subepithelially, representing 0. Giantcell fibroma, first described by weathers and callihan in 1947,1 is a benign, sessile or pedunculated lesion of oral mucosa, seen predominately in the third. They are sometimes seen in association with dermatofibrosarcoma protuberans dfsp, hybrid lesions or may transform or recur as dfsp. Giantcell fibroma is a type of fibroma not associated with trauma or irritation. The current revision, part of the 4 th edition of the who series, was published in 20 and is reflected in the article below 1 classification adipocytic tumors. Clinically it is presented as a painless, sessile, or. Giant cell fibroma gcf is an unusual fibrous mucosal mass with several unique features separating it from other oral fibrous hyperplasias. The giant cell fibroma is a localized reactive proliferation of fibrous tissue, much like the irritation fibroma. Peripheral giant cell granuloma and peripheral ossifying fibroma are clinicopathologically distinct gingival lesions.
Case report giant cell tumor of the maxilla in an 8 year old boy sabhlok s1, shaikh mi2, tripathy r3, mishra s4 abstract 1 central giant cell tumors cgcts of jawbones in pediatric patients present some particular characteristics with regard to their biological behavior. Peripheral giant cell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. The etiology for gcf remains unknown and does not appear to be associated with. A giant cell fibroma, a type of fibrous hyperplasia, was discovered during a preventive patient visit in the dental hygiene clinic at a midwestern university. Pdf benign gingival overgrowths are not uncommon in the oral cavity. The most common oral locations are on the gingiva of the mandible, tongue, and palate. Giant cell fibroma a case report international journal. Many issues are raised with regards to nomenclature, the shared features between the current case and giant cell collagenoma, the true nature of the cellular area in the current lesion, and the histogenesis of giant cells in pleomorphic sclerotic fibroma and pleomorphic fibroma. Giant cell fibromas gcfs are a separate category under fibromas, that was first discovered by weathers and callihan in 1974. The patient, a 19yearold female, presented with a domeshaped lesion of normal mucosal color on the. Apr 10, 20 fibroma and giantcell tumor of tendon sheath.
We describe the case of a young man with giant cell fibroma gcf of the oral cavity. Peripheral giantcell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Giant cell fibromas gcf of the oral cavity are found predominantly in caucasians and rarely in other races. In giant cell fibroblastoma, the tumour is based in the dermis or subcutis. The clinical differential diagnosis of a fibroma depends on its clinical presentation and location and includes giant cell fibroma, neurofibroma, peripheral giant cell granuloma, schwannoma, granular cell tumor, mucocele, and benign and malignant salivary gland tumors eg, see salivary gland neoplasms. A 53yearold man presented in 2009 with a tumor over the. Gingival giant cell fibroma of unusual size medigraphic. The gcf was first described as a separate entity among fibrous hyperplastic soft tissue lesions by weathers and callihan in 1974.
Printable fibroma of tendon sheath surgical pathology. Cutaneous and superficial soft tissue spindle cell proliferation is a commonly encountered diagnostic problem in the daily practice of pathologists and dermatopathologists. An asymptomatic, sessile lesion was excised from the tongue of a young man who had no previous history of chronic irritation. It is often impossible to make a clinical distinction between the two entities, thereby making definitive diagnosis dependent on. Giant fibroadenoma of the breast definition of giant. First reported by weathers and callihan in 1974, gcf is found predominantly in caucasians in first three decades of life with slight female predilection. Giant cell fibroma is a small usually less than 5mm diameter firm lump in the mouth, often with a folded or pebbly surface. Feb 18, 2019 dr ben sutter of eugene or utilizes 10. The giant cell fibroma is a fibrous tumour with distinct clinicopathologic features which sets it apart from the conventional fibroma. A complete surgical excision of oral giant cell fibroma usually results in a cure. The patient, a 19yearold female, presented with a domeshaped lesion of normal mucosal.
Some of the most commonly encountered exophytic gingival lesions are the irritation fibroma, peripheral ossifying fibroma, pyogenic granuloma, and peripheral giant cell granuloma. The tumor is characterized by a locally aggressive behavior with no reported metastatic potential. There are no significant complications due to the tumor. Central giant cell granuloma giant cell lesion of hyperparathyroidism nonodontogenic benign tumors. Aug 01, 2017 cutaneous and superficial soft tissue spindle cell proliferation is a commonly encountered diagnostic problem in the daily practice of pathologists and dermatopathologists. It can occur at any age and on a mucous membrane surface. Giant cell fibroma is an asymptomatic sessile or pedunculated nodule. Giant cell fibroma a variant of oral fibroma, is a rare reactive fibrous connective tissue tumour of the oral cavity. Giant cell fibroma gcf is a benign nonneoplastic lesion first described by weathers and callihan 1974. Differential diagnosis of oral maxillofacial lesions.
It is a reactive localized proliferation of fibrous tissue. Giant cell fibroblastomas are skin and soft tissue tumours that usually arise in childhood. A peripheral giant cell granuloma with extensive osseous. We present a case of a 21yearold woman who had a asymptomatic nodular injury located on the lingual gums at the height of the second upper left premolar. Eversole and rovin compared 279 fibrous hyperplastic lesions that were categorized into four types, namely pyogenic granuloma, peripheral gingival fibroma, peripheral giant cell granuloma, and peripheral ossifying fibroma.
Giant cell fibroma is a type of fibroma not associated with trauma or irritation. These three diseases are associated because they appear. The giant cell fibroma is a benign, fibrous tumor with multiple large fibroblasts, not associated with trauma or chronic irritation. Etiology is unknown and there are various controversies regarding origin of giant multinucleated fibroblasts. Histological findings showed a benign giantcell fibroma. Both are included in clinical differential diagnoses of common benign and reactive gingival epulides in humans. Giant cell fibroma gcf is one such interesting lesion that may clinically mimic a fibroma or a papilloma that can only be diagnosed. Description breast fibroadenomas, abnormal growths of glandular and fibrous tissues, are most common between the ages of 15 and 30, and are found in. Giant cell fibroma definition of giant cell fibroma by. It is a localized reactive proliferation of fibrous connective tissue giant cell fibroma gcf is a benign nonneoplastic lesion first described by weathers and. It usually occurs in young people without any gender predilection.
Pathology confirms it was a giant cell fibroma and the removal kept it from getting bigger. Oral giant cell fibroma is usually present as a mass in the mouth. The purpose of this paper was to contribute two clinically and histologically documented cases of giant cell fibroma in the free gingiva of a 7 and 6 year old boys. The cause of oral giant cell fibroma is unknown and so are the risk factors. Weathers and callihan were the first to describe giant cell fibroma gcf as a separate entity among fibrous soft tissue lesions of the oral cavity, in the early 1970s. The giant cell fibroma gcf is a lesion of fibrous connective tissue origin. Oral giant cell fibromas may occur as new growths that develop over weeks to months. The differential diagnosis included peripheral ossifying fibroma, peripheral giant cell granuloma, and giant cell fibroma. The tumor site could include the tongue, palate, or gums. A rare case of giant cell fibroma in a pediatric patient sangeeta rajesh patankar, nidhi somnath tripathi, pratyusha prakash gaonkar, gokul sridharan department of oral and maxillofacial pathology, ymt dental college, navi mumbai, maharashtra, india.
A rare type of gingival overgrowth monali shah 1, chaitali v rathod 1, vandana shah 2 1 department of periodontics, k. Pdf giant cell fibroma a case report semantic scholar. They considered gcf as a fibrous tumor with distinct diagnostic clinicopathological features. Giant cell fibroma is a type of fibrous tumour of the oral mucosa which rarely affects children under the age of. Sep 12, 2016 giant cell fibroma gcf is a benign nonneoplastic lesion first described by weathers and callihan 1974. Oral fibrous hyperplasias and the giant cell fibroma oral fibrous hyperplasias and the giant cell fibroma savage, n. Clinically it usually manifests as a small, may have be sessilepeduncalate lesion. Please remove adblock adverts are the main source of revenue for dovemed. May 31, 2018 the clinical differential diagnosis of a fibroma depends on its clinical presentation and location and includes giant cell fibroma, neurofibroma, peripheral giant cell granuloma, schwannoma, granular cell tumor, mucocele, and benign and malignant salivary gland tumors eg, see salivary gland neoplasms. The purpose of this paper was to contribute two clinically and histologically documented cases of giant cell fibroma in the free. Printable giant cell fibroblastoma surgical pathology. Gingival enlargement and gingival overgrowth are common features of gingival diseases. It is often impossible to make a clinical distinction between the two entities, thereby making definitive diagnosis dependent on histopathologic features.
Giant cell fibroma gcf is a rare case with unique histopathology. It most commonly occurs on the gums, more commonly on the lower than upper. Peripheral ossifying fibroma pof is a reactive gingival overgrowth which is relatively uncommon in nature. Dermis and subcutis contains hyperchromatic spindle or stellate shaped cells in a collagenous or myxoid matrix with scattered hyperchromatic, multinucleated, floretlike giant cells with prominent nucleoli, similar to those in pleomorphic lipomas.
Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma and peripheral ossifying fibroma. Giant cell fibroblastoma is a rare fibroblastic tumor occurring mainly in young patients. These three diseases are associated because they appear frequently on gingiva. The giant cell fibroma is an interesting nonneoplastic lesion of the oral mucosa. Pofs comprises of, one or more mineralized tissues, including bone, cementum like material or dystrophic calcification, within a matrix of cellular fibroblastic tissue 2. Giant cell fibroma is a type of fibrous tumour of the oral mucosa which rarely affects children under the age of 10. The world health organization who classification of soft tissue tumors is the most widely used pathologic classification system for such disorders.
Giant cell fibroma gcf was described as a new entity of fibrous hyperplastic soft tissue. It was named for its characteristically large, stellateshaped, mononuclear and multinucleated giant cells. Oral fibrous hyperplasias and the giant cell fibroma. Only its peculiar histopathological features help us to distinguish it from them. Cardiac fibroma may be a manifestation of gorlin syndrome. A 53yearold man presented in 2009 with a tumor over the dorsum of his hand and wrist. It belongs to the broad category of fibrous hyperplastic lesions of the oral cavity. Giant cell fibroma gcf is considered a distinct variant among the fibrotic soft tissue lesions. Who classification of tumors of soft tissue radiology. Giant cell fibroma of the buccal mucosa with laser excision.
Pdf giant cell fibroma gcf is considered a distinct variant among the fibrotic soft tissue lesions. It is a type of fibroma not associated with trauma or irritation. The most common site for occurrence of giant cell fibroma is gingiva followed by tongue, buccal mucosa, palate, lip and floor of mouth. Because of these mixed glial and neuronal characteristics, some prefer the term subependymal giant cell tumor. Its occurrence is relatively rare in paediatric patients. Hybrid central odontogenic fibroma with giant cell.
It is painless, often has lobules nodules on its surface. Central odontogenic fibroma cof is an uncommon intraosseous neoplasm of the gnathic bones which is composed of fibrous connective tissue, with or without calcifications, and variable amounts of inactive odontogenic epithelium. Learn indepth information on oral giant cell fibroma, its causes, symptoms, diagnosis, complications, treatment, prevention, and prognosis. A rare case of giant cell fibroma in a pediatric patient.